姓名:云宇
出生年月:1978.05
基本情况:昆明医科大学,基础医学院,教授,博士,博导
行政职务:药理学系主任
社会职务:无
招生专业:药理学
研究领域:高尿酸血症的防治
培养研究生情况:指导硕士生9人,毕业5人,在读4人
电子邮件:yunyu_li@126.com
个人简介:
受教育经历:(按时间倒排序)
2006 /09–2010/07,昆明医科大学,药学院药理系,博士
2003 /09–2006/07,昆明医科大学,基础医学院药理学系,硕士
1996 /09–2001/07,昆明医科大学,临床学院,学士
研究工作经历(按时间倒排序)
2001 /09– 至今,昆明医科大学,基础医学院药理学系,教授
主持或参加科研项目及人才计划项目情况:
1.云南省科技厅科学研究基金,202101ay070001-007,尿酸酶基因敲除大鼠肠道尿酸分布规律及其机制研究,2021.09-2024.10,40万元,在研,主持
2.国家自然科学基金面上项目,81860162,尿酸酶基因敲除模型大鼠的研制,2019.01-2022.12,35万元,在研,主持
3. 云南省教育厅科学研究基金,2018js153,肠道尿酸的特征性分布及其机制研究,2018.05-2021.05,4万元,已结题,主持
4. 云南省科技厅联合基金,2014fz006,从肠道毒素入侵途径探讨下肢、腹部受凉导致普通感冒的发病机制,2014.10-2017.09,10万,已结题,主持
5. 云南省科技厅联合基金,2012fb014,缺血后处理对大鼠肾脏再灌注损伤nrf2/keap1/are通路调节机制的研究,2012.10-2015.09, 10万,已结题,主持
代表性论著(按以下格式填写)
1. 期刊论文:
l yu y, wan x, li d, qi y, li n, luo g, yin h, wang l, qin w, li y, li l, duan w. dieting alleviates hyperuricemia and organ injuries in uricase-deficient rats via down-regulating cell cycle pathway. peerj. 2023;11:e15999.
l yinfang gao, yun yu, wan qin, nan fan, yalin qi, huan chen, weigang duan*. uricase-deficient rats with similarly stable serum uric acid to human’s are sensitive model animals for studying hyperuricemia. plos one. 2022;17(3): e0264696
l nan fan,yun yu, lvyu li, heng xia, xiangxian dong, yongkun li, huan chen, weigang duan*. uricase deficiency causes mild and multiple organ injuries in rats.plos one, 2021; 16(8):e0256594.
l yun yu, nan zhang, xianxiang dong,nan fan,lei wang,yuhui xu, huan chen,and weigang duan*. uricase-deficient rat is generated with crispr/cas9 technique,peer j,8,:e8971 http://doi.org/10.7717/peerj.8971
l dequan liu,yu yun ,dechun yang, xinyu hu, xianxiang dong, nan zhang hua yin,lumei zhang, weigang duan*.what is the biological function of uric acid?an antioxidant for neural protection or a biomarker for cell death,diseasemarker, 2019:4081962.
l 云宇,李月,杨榕,张路梅,董鲜翔,殷华,熊云霞,段为钢.氨丁三醇在体外促尿酸溶解作用,华西药学杂志,2018,33(1):037-041.
l yu yun , hua yin , zhiyi gao, yue li, tao gao, jinlian duan, rong yang, xianxiang dong, lumei zhang, weigang duan*, intestinal tract is an important organ for lowering serum uric acid in rats,plos one, 2017; 12(12):e0190194.
l 云宇,侯肖霖,殷华,柯瑾,段为钢*, 4种去大分子中药注射剂的稳定性研究, 云南中医学院学报,2016,39(04):20~25.
l yu yun, tao gao, yue li, zhiyi gao, jinlian duan, hua yin, weigang duan*, excretory function of intestinal tract enhanced in kidney impaired rats caused by adenine,the scientific world journal,2016, 2016: 1~8
2. 会议论文:
l yu yun#,yi zhang,and weigang duan*, mixed rna duplexes , a new type of neucleic acid inhibit a549 cell line growing,proceedings of the 2015 international conference on, food hygiene, agriculture and animal science, 2015, wuhan,p.r. china, 2015.11.18-11.22
l yu yun#, yi zhang, and weigang duan*, benefits and disadvantages of assay kits in experimental education, international conference on management science, education technology, arts, social science and economics, 2015, qingdao, p.r. china, 2015.11.21-11.25
3. 奖励:云宇,王殿华,褚微微,武步强,朱振东,肾、肝和肠缺血-再灌注损伤及缺血后处理保护机制研究,云南省科技厅, 自然科学奖,三等奖,2012